U.S. Warships Lost to Enemy Action

Only two American warships were lost to enemy fire in the Great War:

Destroyer DD-61 Jacob Jones, sunk by German submarine U-53 off the Isles of Scilly, 6 Dec 1917. Jacob Jones went down in eight minutes, taking 64 men with her and was the first U.S. destroyer ever to be lost to enemy action. (article)

Armored Cruiser AC- 6 San Diego, formerly Pennsylvania, sunk by German U-156 off U.S. east coast 19 July 1918 with six killed. (article)